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Then the Campaign Guide informed me that because I had only captured three Cultists in Scenario Two, I was to start this scenario with two Doom Tokens on Agenda 1

Not only does this shut down many decks that work out of the grave, but it also means that monsters or cards that are destroyed will be much harder to get back from the banish zone

"Macro Cosmos" being activated could obliterate a players turn, as Banished cards are impossible to retrieve from the Graveyard for most Decks

Since mutate's downside is getting hurt by removal, this allows you to recycle your best mutate cards to activate their effects all over again.